Across TCGA patient cohorts, PLXNB2 mutation is significantly associated with the RNA expression of many other genes, with 5,655 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXNB2-associated genes across cancer lineages are ARHGAP11A, NCAPG, and HELLS. Each is linked with PLXNB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLXNB2-to-partner and partner-to-PLXNB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNB2→partner) and Y-score (partner→PLXNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ARHGAP11A →	+0.830	+3.182	.001	.009	3	5
UCEC	NCAPG →	+0.418	+2.010	.005	.001	3	5
UCEC	HELLS →	+0.413	+1.640	<.001	<.001	3	5
COAD	DENND10 →	+0.393	+3.196	<.001	<.001	3	5
LUAD	ZWINT →	+0.777	+2.918	.003	.001	3	5
COAD	KNL1 →	+0.443	+2.515	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,655 associations by consensus.

Exploration

PLXNB2 survival (RNA) · tumor vs normal (RNA) · all PLXNB2 data types