Across TCGA patient cohorts, PLXNA4 mutation is significantly associated with the total protein of many other genes, with 98 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXNA4-associated genes across cancer lineages are INPP4B, 4E-BP1, and GAPDH. Each is linked with PLXNA4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLXNA4-to-partner and partner-to-PLXNA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNA4→partner) and Y-score (partner→PLXNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.374	-2.247	<.001	.001	3	5
STAD	4E-BP1 →	+0.298	+3.321	.007	.008	3	5
STAD	GAPDH →	+0.366	+1.807	.004	.025	3	5
STAD	Caveolin-1 →	-0.792	-1.807	.004	.025	3	5
COAD	eEF2 →	+0.280	+1.724	.001	.002	3	5
LUAD	FASN →	+0.360	+1.700	.006	.038	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

Exploration

PLXNA4 survival (RNA) · tumor vs normal (RNA) · all PLXNA4 data types