Across TCGA cell cohorts, PLXNA4 mutation is significantly associated with the RNA expression of many other genes, with 1,711 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLXNA4-associated genes across cancer lineages are PCDH11Y, MMS22L, and PWWP3A. Each is linked with PLXNA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXNA4-to-partner and partner-to-PLXNA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNA4→partner) and Y-score (partner→PLXNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PCDH11Y →	+0.012	+4.087	<.001	.009	3	3
LARGE_INTESTINE	MMS22L →	+0.740	+1.714	<.001	.006	3	3
LARGE_INTESTINE	PWWP3A →	+0.672	+2.764	<.001	<.001	3	3
LARGE_INTESTINE	B2M →	-1.303	-3.517	.001	<.001	3	3
BREAST	DSPP →	+0.038	+2.736	<.001	.002	3	3
PANCREAS	POU3F2 →	+0.179	+3.169	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,711 associations by consensus.

Exploration

PLXNA4 survival (RNA) · tumor vs normal (RNA) · all PLXNA4 data types