PLXNA3

Across TCGA cell cohorts, PLXNA3 mutation is significantly associated with the RNA expression of many other genes, with 764 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLXNA3-associated genes across cancer lineages are HSD17B6, CSH1, and CBX7. Each is linked with PLXNA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXNA3-to-partner and partner-to-PLXNA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSD17B6 grouped by PLXNA3-low versus PLXNA3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNA3→partner) and Y-score (partner→PLXNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HSD17B6 →	+0.898	+2.145	<.001	.006	3	3
LUNG_NSCLC_LUAD	CSH1 →	+0.043	+3.665	<.001	<.001	3	2
BLOOD_Leukemia	CBX7 →	+0.763	+2.145	.009	.006	3	2
BREAST	R3HDML →	+0.354	+3.614	<.001	.002	3	2
BLOOD_Leukemia	PAIP2 →	+0.466	+3.214	.007	.006	3	2
BLOOD_Leukemia	SIT1 →	+2.504	+3.366	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 764 associations by consensus.

HSD17B6 by PLXNA3 expression — BLOOD_Leukemia

Explore this box plot interactively →