PLXDC2

Across TCGA patient cohorts, PLXDC2 mutation is significantly associated with the RNA expression of many other genes, with 3,036 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXDC2-associated genes across cancer lineages are RNU6-173P, POLE, and GLRX5. Each is linked with PLXDC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXDC2-to-partner and partner-to-PLXDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-173P grouped by PLXDC2-low versus PLXDC2-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXDC2→partner) and Y-score (partner→PLXDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RNU6-173P →	+0.268	+4.906	<.001	.005	3	3
UCEC	POLE →	+0.427	+1.990	<.001	<.001	3	3
UCEC	GLRX5 →	+0.306	+2.254	.004	<.001	3	3
UCEC	KMT5A →	+0.346	+2.311	<.001	<.001	3	3
UCEC	NF2 →	+0.338	+1.958	.004	<.001	3	3
LUAD	WDR5 →	+0.525	+3.287	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,036 associations by consensus.

RNU6-173P by PLXDC2 expression — OV

Explore this box plot interactively →