PLXDC2

Across TCGA patient cohorts, PLXDC2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXDC2-associated genes across cancer lineages are Cyclin-B1, INPP4B, and IRS1. Each is linked with PLXDC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXDC2-to-partner and partner-to-PLXDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PLXDC2-low versus PLXDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXDC2→partner) and Y-score (partner→PLXDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.566	+2.807	.001	.003	3	3
UCEC	INPP4B →	-0.265	-1.700	.011	.040	3	3
SKCM	IRS1 →	+0.128	+1.754	.011	.047	3	2
SKCM	SCD →	-0.108	-1.765	.024	.012	3	2
UCEC	EGFR_pY1068 →	-0.178	-1.678	.029	.021	3	2
UCEC	A-Raf_pS299 →	-0.085	-1.584	.028	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Cyclin-B1 by PLXDC2 expression — UCEC

Explore this box plot interactively →