PLXDC2

Across TCGA cell cohorts, PLXDC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,221 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PLXDC2-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Alternative mRNA splicing, via spliceosome. Each is linked with PLXDC2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PLXDC2-to-partner and partner-to-PLXDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by PLXDC2-low versus PLXDC2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXDC2→partner) and Y-score (partner→PLXDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of myoblast fusion →	+0.096	+1.507	<.001	<.001	3	9
SOFT_TISSUE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.091	+1.465	<.001	<.001	3	8
OVARY	Alternative mRNA splicing, via spliceosome →	+0.096	+1.424	<.001	<.001	3	8
BLOOD_Leukemia	Negative regulation of respiratory burst involved in inflammatory response →	+0.109	+1.338	<.001	<.001	3	7
BLOOD_Leukemia	Negative regulation of respiratory burst →	+0.109	+1.338	<.001	<.001	3	7
SKIN	Adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway →	+0.124	+0.790	.008	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,221 associations by consensus.

Negative regulation of myoblast fusion by PLXDC2 expression — SOFT_TISSUE

Explore this box plot interactively →