PLXDC2

Across TCGA cell cohorts, PLXDC2 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PLXDC2-associated genes across cancer lineages are POTEB3, OR13C7, and ACSM1. Each is linked with PLXDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLXDC2-to-partner and partner-to-PLXDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POTEB3 grouped by PLXDC2-low versus PLXDC2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXDC2→partner) and Y-score (partner→PLXDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	POTEB3 →	+0.008	+3.635	.004	.007	3	2
LUNG_NSCLC_LUAD	OR13C7 →	+0.021	+3.944	<.001	.006	3	2
SOFT_TISSUE	ACSM1 →	+0.313	+3.865	<.001	.006	3	1
SOFT_TISSUE	FMR1NB →	+0.274	+4.000	<.001	.004	3	1
SOFT_TISSUE	FTMT →	+0.052	+4.392	<.001	.004	3	1
LUNG_NSCLC_LUAD	LILRA1 →	+0.020	+3.043	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

POTEB3 by PLXDC2 expression — SOFT_TISSUE

Explore this box plot interactively →