PLXDC1

Across TCGA patient cohorts, PLXDC1 mutation is significantly associated with the RNA expression of many other genes, with 3,627 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXDC1-associated genes across cancer lineages are IER3IP1, DCAF1, and VAPA. Each is linked with PLXDC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLXDC1-to-partner and partner-to-PLXDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IER3IP1 grouped by PLXDC1-low versus PLXDC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXDC1→partner) and Y-score (partner→PLXDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IER3IP1 →	+0.670	+3.267	.001	.008	3	4
UCEC	DCAF1 →	+0.584	+3.708	<.001	<.001	3	4
COAD	VAPA →	+0.529	+3.196	.004	.009	3	3
COAD	MICU1 →	+0.544	+3.183	<.001	.009	3	3
COAD	KDSR →	+0.518	+3.210	.007	.009	3	3
COAD	SMAD4 →	+0.729	+3.196	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,627 associations by consensus.

IER3IP1 by PLXDC1 expression — COAD

Explore this box plot interactively →