PLXDC1

Across TCGA patient cohorts, PLXDC1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXDC1-associated genes across cancer lineages are YB-1_pS102, TAZ, and CD49b. Each is linked with PLXDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXDC1-to-partner and partner-to-PLXDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YB-1_pS102 grouped by PLXDC1-low versus PLXDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXDC1→partner) and Y-score (partner→PLXDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YB-1_pS102 →	-0.221	-2.321	.004	.034	3	3
SKCM	TAZ →	+0.146	+3.182	.029	.009	3	2
SKCM	CD49b →	+0.246	+1.717	.012	.026	3	2
UCEC	FOXO3a_pS318_S321 →	-0.173	-3.575	.001	.002	3	2
UCEC	JNK_pT183_Y185 →	-0.236	-2.700	<.001	.006	3	2
UCEC	MAPK_pT202_Y204 →	-0.473	-2.321	.017	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

YB-1_pS102 by PLXDC1 expression — UCEC

Explore this box plot interactively →