PLXDC1

Across TCGA cell cohorts, PLXDC1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLXDC1-associated genes across cancer lineages are MAGEB4, HRG, and AKR1D1. Each is linked with PLXDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLXDC1-to-partner and partner-to-PLXDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by PLXDC1-low versus PLXDC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXDC1→partner) and Y-score (partner→PLXDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	2
BLOOD_Leukemia	HRG →	+0.333	+4.177	<.001	.001	3	1
BLOOD_Leukemia	AKR1D1 →	+0.014	+3.450	.005	.004	3	1
BLOOD_Leukemia	MMP27 →	+0.013	+3.969	<.001	.009	3	1
BLOOD_Leukemia	ZIC3 →	+0.012	+3.475	<.001	.006	3	1
BLOOD_Leukemia	WFDC12 →	+0.163	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MAGEB4 by PLXDC1 expression — LARGE_INTESTINE

Explore this box plot interactively →