PLVAP

Across TCGA patient cohorts, PLVAP mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLVAP-associated genes across cancer lineages are Akt_pT308, PRAS40_pT246, and MSH2. Each is linked with PLVAP in more than 3 cancer types. Because this analysis shows association rather than direction, both PLVAP-to-partner and partner-to-PLVAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by PLVAP-low versus PLVAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLVAP→partner) and Y-score (partner→PLVAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.627	+2.700	.005	.005	3	4
UCEC	PRAS40_pT246 →	+0.150	+2.222	.015	.010	3	3
UCEC	MSH2 →	-0.368	-2.807	<.001	<.001	3	2
UCEC	MSH6 →	-0.474	-2.990	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.382	-2.807	<.001	<.001	3	2
UCEC	Tuberin_pT1462 →	+0.165	+1.584	.046	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Akt_pT308 by PLVAP expression — UCEC

Explore this box plot interactively →