PLSCR5

Across TCGA patient cohorts, PLSCR5 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLSCR5-associated genes across cancer lineages are PDK1_pS241, Fibronectin, and ACC1. Each is linked with PLSCR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLSCR5-to-partner and partner-to-PLSCR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by PLSCR5-low versus PLSCR5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLSCR5→partner) and Y-score (partner→PLSCR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1_pS241 →	+0.173	+2.515	.009	.001	3	2
UCEC	Fibronectin →	-0.260	-1.584	.045	.036	3	1
UCEC	ACC1 →	+0.398	+3.183	.005	.009	3	1
UCEC	Ku80 →	+0.250	+2.013	.007	.005	3	1
UCEC	MEK1 →	+0.346	+3.584	.015	.002	3	1
UCEC	Notch1 →	+0.159	+2.009	.004	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

PDK1_pS241 by PLSCR5 expression — UCEC

Explore this box plot interactively →