PLSCR4

Across TCGA patient cohorts, PLSCR4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLSCR4-associated genes across cancer lineages are Notch1, 4E-BP1_pT37_T46, and EGFR_pY1068. Each is linked with PLSCR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLSCR4-to-partner and partner-to-PLSCR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PLSCR4-low versus PLSCR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLSCR4→partner) and Y-score (partner→PLSCR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.226	+3.472	<.001	.002	3	2
UCEC	4E-BP1_pT37_T46 →	-0.384	-3.308	.016	.009	3	2
UCEC	EGFR_pY1068 →	-0.232	-2.222	.029	.011	3	1
UCEC	MEK1 →	+0.381	+2.222	.014	.011	3	1
UCEC	mTOR →	-0.186	-2.321	.006	.034	3	1
UCEC	p21 →	+0.186	+3.013	.022	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Notch1 by PLSCR4 expression — UCEC

Explore this box plot interactively →