PLSCR4

Across TCGA cell cohorts, PLSCR4 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLSCR4-associated genes across cancer lineages are FMO1, CCDC70, and VCY1B. Each is linked with PLSCR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLSCR4-to-partner and partner-to-PLSCR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMO1 grouped by PLSCR4-low versus PLSCR4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLSCR4→partner) and Y-score (partner→PLSCR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FMO1 →	+0.084	+3.921	.008	.001	3	1
LARGE_INTESTINE	CCDC70 →	+0.044	+3.263	<.001	.006	3	1
LARGE_INTESTINE	VCY1B →	+0.783	+2.936	<.001	.007	3	1
LARGE_INTESTINE	ASTN1 →	+0.602	+3.825	<.001	.006	3	1
LARGE_INTESTINE	DNASE1L3 →	+0.095	+3.491	<.001	.008	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.412	+2.925	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FMO1 by PLSCR4 expression — LARGE_INTESTINE

Explore this box plot interactively →