PLSCR2

Across TCGA patient cohorts, PLSCR2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLSCR2-associated genes across cancer lineages are p21, XBP1, and EGFR_pY1068. Each is linked with PLSCR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLSCR2-to-partner and partner-to-PLSCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by PLSCR2-low versus PLSCR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLSCR2→partner) and Y-score (partner→PLSCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.153	+2.000	.042	.010	3	2
UCEC	XBP1 →	-0.172	-1.986	.001	.029	3	2
UCEC	EGFR_pY1068 →	-0.239	-2.502	.015	.002	3	1
UCEC	GATA6 →	-0.154	-3.155	.011	.018	3	1
UCEC	Heregulin →	-0.109	-2.308	.025	.033	3	1
UCEC	INPP4B →	-0.327	-2.807	.010	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

p21 by PLSCR2 expression — UCEC

Explore this box plot interactively →