PLSCR2

Across TCGA cell cohorts, PLSCR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,602 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PLSCR2-associated GO terms across cancer lineages are Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity, Innate immune response-activating signaling pathway, and Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. Each is linked with PLSCR2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PLSCR2-to-partner and partner-to-PLSCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity grouped by PLSCR2-low versus PLSCR2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLSCR2→partner) and Y-score (partner→PLSCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity →	+0.176	+0.146	<.001	<.001	3	9
BREAST	Innate immune response-activating signaling pathway →	+0.056	+0.180	<.001	<.001	3	6
BREAST	Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains →	+0.054	+0.169	<.001	<.001	3	6
BLOOD_Lymphoma	Viral gene expression →	+0.080	+0.082	<.001	.002	3	6
OVARY	Negative regulation of protein catabolic process →	+0.064	+0.149	<.001	<.001	3	6
LUNG_NSCLC_LUAD	Germinal center formation →	-0.127	-0.149	.003	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,602 associations by consensus.

Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity by PLSCR2 expression — OVARY

Explore this box plot interactively →