Across TCGA pan-cancer cohorts, PLSCR1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PLSCR1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PLSCR1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PLSCR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where PLSCR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.276	0.473	<.001	57	view →
CCRCC	OS	Median	All	0.768	0.919	.007	20	view →
HNSC	OS	Tertile	IV	0.903	0.608	.008	17	view →
LSCC	DFS	Median	III,IV	1.000	0.580	.003	17	view →
GBM	DFS	Tertile	All	0.209	0.408	.001	10	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PLSCR1 tumor-vs-normal RNA expression · all PLSCR1 data types