Across TCGA patient cohorts, PLSCR1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLSCR1-associated genes across cancer lineages are GSK-3a-b_pS21_S9, JNK2, and Myosin-IIa_pS1943. Each is linked with PLSCR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLSCR1-to-partner and partner-to-PLSCR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLSCR1→partner) and Y-score (partner→PLSCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.458	+2.331	.021	.019	3	1
UCEC	JNK2 →	+0.307	+2.834	<.001	.034	3	1
UCEC	Myosin-IIa_pS1943 →	+0.256	+2.598	.007	.006	3	1
UCEC	Rab25 →	-0.317	-2.584	.040	.011	3	1
UCEC	Annexin-1 →	+0.666	+3.019	.006	.019	3	1
UCEC	Tuberin →	+0.414	+2.584	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

PLSCR1 survival (RNA) · tumor vs normal (RNA) · all PLSCR1 data types