PLS3

Across TCGA patient cohorts, PLS3 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,325 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PLS3-associated proteins across cancer lineages are PLS3_S293, CNN3, and RAI14. Each is linked with PLS3 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLS3-to-partner and partner-to-PLS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLS3 versus PLS3_S293 in HNSC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLS3→partner) and Y-score (partner→PLS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLS3_S293 →	+1.083	+0.925	<.001	<.001	3	7
OV	CNN3 →	+0.735	+1.242	<.001	<.001	3	7
OV	RAI14 →	+0.396	+1.145	<.001	<.001	3	6
OV	SNX18 →	+0.595	+1.066	.003	.006	3	6
GBM	TRIP6 →	+0.387	+0.927	<.001	<.001	3	6
UCEC	PLS3_S339 →	+0.641	+1.153	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,325 associations by consensus.

PLS3 vs PLS3_S293 — HNSC

Explore this scatter interactively →