PLS3

Across TCGA patient cohorts, PLS3 mutation is significantly associated with the RNA expression of many other genes, with 4,245 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLS3-associated genes across cancer lineages are DNAJB8-AS1, RPS17P11, and SNX18P23. Each is linked with PLS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLS3-to-partner and partner-to-PLS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJB8-AS1 grouped by PLS3-low versus PLS3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLS3→partner) and Y-score (partner→PLS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DNAJB8-AS1 →	+0.016	+3.224	<.001	.007	3	2
READ	RPS17P11 →	+0.228	+4.653	<.001	.007	3	2
READ	SNX18P23 →	+0.057	+4.653	<.001	.007	3	2
UCEC	GZMH →	+0.959	+2.399	<.001	<.001	3	2
UCEC	GZMB →	+1.091	+2.378	<.001	<.001	3	2
UCEC	NKG7 →	+1.024	+2.389	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,245 associations by consensus.

DNAJB8-AS1 by PLS3 expression — SKCM

Explore this box plot interactively →