PLS3-AS1

Across TCGA pan-cancer cohorts, PLS3-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PLS3-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PLS3-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PLS3-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LUSC show a favorable association.

UCS, KIRP, and THCA are the cancer types where PLS3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	IV	0.952	0.367	.001	134	view →
KIRP	OS	Median	All	0.885	0.973	<.001	76	view →
THCA	DFS	Median	II,III,IV	0.485	0.814	<.001	75	view →
BRCA	DFS	Tertile	II,III,IV	0.911	0.963	<.001	48	view →
COAD	OS	Tertile	II,III,IV	0.807	0.914	.004	42	view →
THYM	DFS	Quartile	All	0.645	0.947	.003	40	view →
LGG	OS	Median	All	0.747	0.863	<.001	37	view →
PAAD	DFS	Quartile	All	0.167	0.388	.005	30	view →
UCEC	DFS	Quartile	All	0.848	0.910	.018	24	view →
LUSC	OS	Median	All	0.807	0.716	.002	22	view →
CHOL	OS	Tertile	All	0.143	0.862	.005	21	view →
SKCM	OS	Tertile	IV	0.097	0.728	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PLS3-AS1–UCS (DFS)

Open the UCS breakdown →