PLS1-AS1

Across TCGA pan-cancer cohorts, PLS1-AS1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated PLS1-AS1 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher PLS1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLS1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

THCA, ACC, and PAAD are the cancer types where PLS1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	All	0.392	0.817	<.001	108	view →
ACC	OS	Tertile	All	0.185	0.821	<.001	72	view →
PAAD	OS	Tertile	All	0.218	0.505	<.001	60	view →
BLCA	DFS	Tertile	II,III,IV	0.449	0.633	.001	54	view →
BRCA	DFS	Tertile	III,IV	0.252	0.519	.033	48	view →
UCS	OS	Tertile	All	0.885	0.501	.014	30	view →
GBM	DFS	Tertile	All	0.074	0.296	<.001	18	view →
LIHC	DFS	Tertile	All	0.365	0.556	.010	18	view →
READ	OS	Tertile	All	1.000	0.559	.016	12	view →
THYM	DFS	Tertile	All	0.459	0.933	<.001	9	view →
SARC	DFS	Tertile	All	0.148	0.594	.016	9	view →
COAD	DFS	Tertile	III,IV	0.224	0.580	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

PLS1-AS1–THCA (DFS)

Open the THCA breakdown →