PLRG1

Across TCGA patient cohorts, PLRG1 mutation is significantly associated with the RNA expression of many other genes, with 2,184 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLRG1-associated genes across cancer lineages are RNA5SP413, RNA5SP417, and RNA5SP422. Each is linked with PLRG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLRG1-to-partner and partner-to-PLRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by PLRG1-low versus PLRG1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLRG1→partner) and Y-score (partner→PLRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP413 →	+1.467	+4.344	<.001	<.001	3	3
LUSC	RNA5SP417 →	+1.059	+4.145	<.001	.001	3	3
LUSC	RNA5SP422 →	+0.972	+4.996	<.001	<.001	3	3
LUSC	RNA5SP423 →	+0.565	+4.148	<.001	.008	3	3
UCEC	RNA5SP412 →	+0.471	+2.092	<.001	<.001	3	3
UCEC	PTMAP9 →	+0.601	+2.346	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,184 associations by consensus.

RNA5SP413 by PLRG1 expression — LUSC

Explore this box plot interactively →