PLRG1

Across TCGA cell cohorts, PLRG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,653 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PLRG1-associated GO terms across cancer lineages are Depurination, DNA damage tolerance, and DNA alkylation repair. Each is linked with PLRG1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PLRG1-to-partner and partner-to-PLRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Depurination grouped by PLRG1-low versus PLRG1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLRG1→partner) and Y-score (partner→PLRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Depurination →	+0.133	+0.830	<.001	.001	3	13
SKIN	DNA damage tolerance →	+0.078	+0.535	<.001	<.001	3	12
PANCREAS	DNA alkylation repair →	+0.108	+0.402	<.001	<.001	3	12
LUNG_SCLC	R-loop processing →	+0.089	+0.425	<.001	<.001	3	11
BREAST	Positive regulation of mitotic cell cycle →	+0.091	+0.675	<.001	<.001	3	10
BLOOD_Myeloma	Protein deubiquitination →	+0.044	+0.836	.001	.009	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,653 associations by consensus.

Depurination by PLRG1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →