PLPPR5

Across TCGA patient cohorts, PLPPR5 mutation is significantly associated with the RNA expression of many other genes, with 2,645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPPR5-associated genes across cancer lineages are SUCLA2, RPA1, and NDUFA6. Each is linked with PLPPR5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLPPR5-to-partner and partner-to-PLPPR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUCLA2 grouped by PLPPR5-low versus PLPPR5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPPR5→partner) and Y-score (partner→PLPPR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SUCLA2 →	+0.549	+2.346	.005	.003	3	3
UCEC	RPA1 →	+0.648	+2.895	<.001	<.001	3	3
UCEC	NDUFA6 →	+0.544	+2.885	<.001	<.001	3	3
HNSC	MIR128-1 →	+0.459	+5.912	<.001	.002	3	2
UCEC	EI24 →	+0.494	+2.392	<.001	<.001	3	2
UCEC	SEC24D →	+0.742	+2.048	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,645 associations by consensus.

SUCLA2 by PLPPR5 expression — UCEC

Explore this box plot interactively →