PLPPR4

Across TCGA patient cohorts, PLPPR4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,448 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLPPR4-associated genes across cancer lineages are PRODH, SEPTIN3, and CYP2D6. Each is linked with PLPPR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPPR4-to-partner and partner-to-PLPPR4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLPPR4 versus PRODH in GBM, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPPR4→partner) and Y-score (partner→PLPPR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+1.032	+0.503	<.001	<.001	3	1
GBM	SEPTIN3 →	+0.898	+0.432	<.001	<.001	3	1
GBM	CYP2D6 →	+0.602	+0.371	.004	.003	3	1
GBM	RASL10A →	+1.119	+0.562	<.001	<.001	3	1
GBM	NEFH →	+0.936	+0.323	<.001	<.001	3	1
GBM	RASD2 →	+0.785	+0.566	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,448 associations by consensus.

PLPPR4 vs PRODH — GBM

Explore this scatter interactively →