PLPPR4

Across TCGA patient cohorts, PLPPR4 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPPR4-associated genes across cancer lineages are FoxM1, STAT3_pY705, and 4E-BP1. Each is linked with PLPPR4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLPPR4-to-partner and partner-to-PLPPR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by PLPPR4-low versus PLPPR4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPPR4→partner) and Y-score (partner→PLPPR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.226	+1.919	.009	.008	3	4
LUAD	STAT3_pY705 →	-0.391	-2.000	<.001	.002	3	4
UCEC	4E-BP1 →	+0.385	+2.169	<.001	<.001	3	4
STAD	PCNA →	+0.261	+3.000	.044	.034	2	4
STAD	Rictor_pT1135 →	-0.173	-3.000	.012	.033	3	3
LUSC	Src_pY527 →	-0.446	-2.990	.033	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

FoxM1 by PLPPR4 expression — LUAD

Explore this box plot interactively →