PLPPR3

Across TCGA patient cohorts, PLPPR3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPPR3-associated genes across cancer lineages are PCNA, Rictor_pT1135, and STAT5a. Each is linked with PLPPR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPPR3-to-partner and partner-to-PLPPR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PLPPR3-low versus PLPPR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPPR3→partner) and Y-score (partner→PLPPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.252	+3.000	.043	.036	3	1
UCEC	Rictor_pT1135 →	-0.126	-3.000	.033	.037	3	1
UCEC	STAT5a →	+0.636	+3.000	.005	.036	3	1
UCEC	ATM →	-0.651	-3.000	.012	.037	3	1
UCEC	Caspase-8 →	-0.292	-3.000	.044	.036	3	1
UCEC	Annexin-1 →	+0.755	+3.000	.013	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PCNA by PLPPR3 expression — UCEC

Explore this box plot interactively →