PLPPR1

Across TCGA patient cohorts, PLPPR1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPPR1-associated genes across cancer lineages are PKC-a_pS657, Shc_pY317, and ASNS. Each is linked with PLPPR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPPR1-to-partner and partner-to-PLPPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a_pS657 grouped by PLPPR1-low versus PLPPR1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPPR1→partner) and Y-score (partner→PLPPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-a_pS657 →	+0.363	+1.887	.026	.029	3	2
UCEC	Shc_pY317 →	-0.140	-1.584	.005	.034	3	2
UCEC	ASNS →	+0.366	+1.925	.002	.004	3	2
UCEC	C-Raf →	+0.170	+1.765	<.001	.013	3	2
SKCM	EGFR_pY1068 →	+0.156	+3.459	.021	.005	3	1
SKCM	AMPK_pT172 →	+0.291	+3.321	.036	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PKC-a_pS657 by PLPPR1 expression — SKCM

Explore this box plot interactively →