PLPP7

Across TCGA pan-cancer cohorts, PLPP7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PLPP7’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PLPP7 RNA is repressed in tumor relative to normal tissue. In most cancer types PLPP7 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and UCEC are the cancer types where PLPP7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLPP7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−2.637	<.001	10	view →
KICH	Male	All	−1.697	<.001	10	view →
UCEC	All	III,IV	−2.786	<.001	8	view →
BRCA	All	III,IV	−1.152	<.001	6	view →
KIRP	All	All	−0.732	.003	6	view →
LUAD	All	All	−0.378	<.001	5	view →
LIHC	All	All	+0.326	.002	5	view →
COAD	All	II,III,IV	−0.540	.002	4	view →
LUSC	All	All	−0.432	<.001	3	view →
READ	Female	All	−1.877	.005	2	view →
HNSC	Male	IV	−1.600	.036	2	view →
PRAD	All	All	−0.911	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PLPP7–BLCA

Open the BLCA breakdown →