Across TCGA pan-cancer cohorts, PLPP6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PLPP6 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PLPP6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PLPP6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where PLPP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	1.000	0.815	.002	20	view →
CCRCC	OS	Tertile	II,III,IV	0.992	0.570	.004	10	view →
LSCC	DFS	Median	All	0.692	0.872	.039	2	view →
HNSC	DFS	Median	III,IV	0.906	1.000	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PLPP6 tumor-vs-normal RNA expression · all PLPP6 data types