Across TCGA patient cohorts, PLPP6 protein abundance is significantly associated with the RNA expression of many other genes, with 7,648 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLPP6-associated genes across cancer lineages are FUBP3, PSAT1, and DMAC1. Each is linked with PLPP6 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLPP6-to-partner and partner-to-PLPP6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP6→partner) and Y-score (partner→PLPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FUBP3 →	+0.283	+0.254	.003	.008	3	3
LSCC	PSAT1 →	+1.044	+0.312	<.001	.006	3	3
LSCC	DMAC1 →	+0.599	+0.501	<.001	<.001	3	3
LSCC	RANBP6 →	+0.614	+0.372	<.001	<.001	3	3
GBM	NR6A1 →	+0.792	+0.480	<.001	.001	3	3
GBM	PANK1 →	+0.520	+0.400	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,648 associations by consensus.

Exploration

PLPP6 survival (RNA) · tumor vs normal (RNA) · all PLPP6 data types