Across TCGA patient cohorts, PLPP6 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPP6-associated genes across cancer lineages are MEK1, Smad1, and Caspase-8. Each is linked with PLPP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPP6-to-partner and partner-to-PLPP6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP6→partner) and Y-score (partner→PLPP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.374	+2.459	.034	.019	3	2
UCEC	Smad1 →	+0.192	+2.459	.011	.020	3	2
UCEC	Caspase-8 →	-0.342	-3.321	.004	.010	3	2
UCEC	EGFR_pY1068 →	-0.321	-2.459	.008	.020	3	1
UCEC	eIF4E →	+0.275	+2.459	.006	.020	3	1
UCEC	ACC1 →	+0.420	+3.013	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

PLPP6 survival (RNA) · tumor vs normal (RNA) · all PLPP6 data types