Across TCGA patient cohorts, PLPP4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,922 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLPP4-associated genes across cancer lineages are GRK3, LGALS1, and PIK3IP1. Each is linked with PLPP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPP4-to-partner and partner-to-PLPP4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP4→partner) and Y-score (partner→PLPP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GRK3 →	+0.941	+1.165	.001	<.001	3	1
GBM	LGALS1 →	-1.117	-0.845	.005	.007	3	1
GBM	PIK3IP1 →	+1.413	+1.064	<.001	<.001	3	1
GBM	RASL10A →	+1.536	+1.241	.009	<.001	3	1
GBM	CBX7 →	+0.951	+1.276	.003	<.001	3	1
GBM	SYNGR1 →	+1.179	+0.760	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,922 associations by consensus.

Exploration

PLPP4 survival (RNA) · tumor vs normal (RNA) · all PLPP4 data types