Across TCGA patient cohorts, PLPP4 mutation is significantly associated with the RNA expression of many other genes, with 370 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PLPP4-associated genes across cancer lineages are HMGN2P7, MIR610, and TMEM241. Each is linked with PLPP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLPP4-to-partner and partner-to-PLPP4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP4→partner) and Y-score (partner→PLPP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HMGN2P7 →	+0.355	+3.700	<.001	.001	3	3
HNSC	MIR610 →	+0.457	+5.912	<.001	.002	3	2
SKCM	TMEM241 →	+0.446	+3.195	.005	.009	3	2
SKCM	DNA2 →	+0.623	+2.732	.002	.003	3	2
SKCM	CDAN1 →	+0.400	+2.706	.007	.003	3	2
CESC	OR6S1 →	+0.065	+4.698	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 370 associations by consensus.

Exploration

PLPP4 survival (RNA) · tumor vs normal (RNA) · all PLPP4 data types