Across TCGA cell cohorts, PLPP4 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PLPP4-associated genes across cancer lineages are PATE4, OR10K2, and PABPC1L2A. Each is linked with PLPP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPP4-to-partner and partner-to-PLPP4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP4→partner) and Y-score (partner→PLPP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PATE4 →	+0.036	+4.095	<.001	.009	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	1
BREAST	PRAMEF4 →	+0.036	+5.781	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	RESP18 →	+0.040	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

PLPP4 survival (RNA) · tumor vs normal (RNA) · all PLPP4 data types