PLPP2

Across TCGA pan-cancer cohorts, PLPP2 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PLPP2 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PLPP2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PLPP2 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

CESC, READ, and LIHC are the cancer types where PLPP2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.047	0.875	<.001	24	view →
READ	DFS	Median	All	0.084	0.845	<.001	12	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	9	view →
COAD	DFS	Median	II,III,IV	0.145	0.687	.001	6	view →
SKCM	DFS	Median	III,IV	1.000	0.250	.037	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PLPP2–CESC (OS)

Open the CESC breakdown →