PLPP2

Across TCGA cell cohorts, PLPP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,796 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLPP2-associated GO terms across cancer lineages are Attachment of spindle microtubules to kinetochore, Bundle of His cell to Purkinje myocyte communication, and Establishment or maintenance of transmembrane electrochemical gradient. Each is linked with PLPP2 in more than 7 cancer types. Because this analysis shows association rather than direction, both PLPP2-to-partner and partner-to-PLPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Attachment of spindle microtubules to kinetochore grouped by PLPP2-low versus PLPP2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP2→partner) and Y-score (partner→PLPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Attachment of spindle microtubules to kinetochore →	-0.074	-1.762	.009	.003	3	8
PANCREAS	Bundle of His cell to Purkinje myocyte communication →	+0.269	+0.913	<.001	<.001	3	7
SOFT_TISSUE	Establishment or maintenance of transmembrane electrochemical gradient →	+0.187	+2.224	.008	.003	3	6
BONE	Synaptic vesicle fusion to presynaptic active zone membrane →	-0.126	-1.656	.004	.002	3	6
BONE	Vesicle fusion to plasma membrane →	-0.126	-1.656	.004	.002	3	6
LUNG_NSCLC_LUSC	Regulation of multicellular organism growth →	+0.114	+0.934	.003	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,796 associations by consensus.

Attachment of spindle microtubules to kinetochore by PLPP2 expression — KIDNEY

Explore this box plot interactively →