PLPP1

Across TCGA pan-cancer cohorts, PLPP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PLPP1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PLPP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PLPP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

PDAC, GBM, and CCRCC are the cancer types where PLPP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.301	0.823	<.001	52	view →
GBM	DFS	Quartile	All	0.305	0.553	.022	4	view →
CCRCC	DFS	Median	All	0.837	1.000	.016	2	view →
LUAD	DFS	Tertile	II,III,IV	1.000	0.547	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PLPP1–PDAC (OS)

Open the PDAC breakdown →