PLPP1

Across TCGA patient cohorts, PLPP1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPP1-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR, and A-Raf_pS299. Each is linked with PLPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPP1-to-partner and partner-to-PLPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PLPP1-low versus PLPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP1→partner) and Y-score (partner→PLPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.669	+3.926	.005	<.001	3	2
UCEC	EGFR →	-0.172	-3.321	.007	.010	3	1
UCEC	A-Raf_pS299 →	-0.115	-2.321	.016	.034	3	1
UCEC	HER3_pY1289 →	+0.080	+3.321	.021	.009	3	1
UCEC	Ku80 →	+0.301	+2.428	.001	.002	3	1
UCEC	Notch1 →	+0.184	+2.472	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Caspase-7-cleavedD198 by PLPP1 expression — UCEC

Explore this box plot interactively →