PLPP1

Across TCGA cell cohorts, PLPP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,341 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLPP1-associated GO terms across cancer lineages are Androgen receptor signaling pathway, Ceramide metabolic process, and Sphingolipid catabolic process. Each is linked with PLPP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PLPP1-to-partner and partner-to-PLPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Androgen receptor signaling pathway grouped by PLPP1-low versus PLPP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP1→partner) and Y-score (partner→PLPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Androgen receptor signaling pathway →	+0.131	+1.661	.001	.001	3	13
BONE	Ceramide metabolic process →	+0.107	+1.190	<.001	<.001	3	12
BONE	Sphingolipid catabolic process →	+0.147	+1.071	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.069	+1.772	.001	.001	3	9
BONE	Regulation of SMAD protein signal transduction →	+0.106	+1.454	<.001	<.001	3	9
BONE	Sphingolipid metabolic process →	+0.096	+1.799	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,341 associations by consensus.

Androgen receptor signaling pathway by PLPP1 expression — BONE

Explore this box plot interactively →