PLPP1

Across TCGA cell cohorts, PLPP1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLPP1-associated genes across cancer lineages are ITGAD and ACSM6. Each is linked with PLPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPP1-to-partner and partner-to-PLPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by PLPP1-low versus PLPP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPP1→partner) and Y-score (partner→PLPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.015	+4.095	<.001	.009	3	1
LARGE_INTESTINE	ACSM6 →	+0.035	+4.169	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

ITGAD by PLPP1 expression — LARGE_INTESTINE

Explore this box plot interactively →