PLPBP

Across TCGA pan-cancer cohorts, PLPBP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PLPBP data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PLPBP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PLPBP expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where PLPBP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.918	.012	60	view →
CCRCC	DFS	Tertile	III,IV	0.731	0.326	.002	35	view →
PDAC	OS	Median	IV	0.491	0.836	.024	13	view →
LUAD	DFS	Quartile	II,III,IV	0.822	0.208	.008	8	view →
HNSC	OS	Median	All	0.636	0.772	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PLPBP–COAD (DFS)

Open the COAD breakdown →