PLPBP

Across TCGA pan-cancer cohorts, PLPBP mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PLPBP’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PLPBP mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PLPBP is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where PLPBP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLPBP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	−0.654	<.001	12	view →
COAD	All	All	−0.106	<.001	10	view →
HNSC	Female	All	−0.390	<.001	9	view →
PDAC	Female	All	−1.110	<.001	8	view →
LUAD	All	III,IV	−0.203	<.001	8	view →
LSCC	Female	III,IV	−0.393	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PLPBP–CCRCC

Open the CCRCC breakdown →