PLPBP

Across TCGA patient cohorts, PLPBP protein abundance is significantly associated with the RNA expression of many other genes, with 9,575 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PLPBP-associated genes across cancer lineages are ASH2L, BRF2, and ERLIN2. Each is linked with PLPBP in more than 8 cancer types. Because this analysis shows association rather than direction, both PLPBP-to-partner and partner-to-PLPBP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLPBP versus ASH2L in LSCC, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPBP→partner) and Y-score (partner→PLPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASH2L →	+0.889	+0.438	<.001	<.001	3	9
HNSC	BRF2 →	+0.953	+0.478	.001	<.001	3	8
BRCA	ERLIN2 →	+1.123	+0.474	<.001	<.001	3	8
LSCC	NSD3 →	+0.991	+0.604	<.001	<.001	3	8
HNSC	BAG4 →	+1.049	+0.546	<.001	<.001	3	8
OV	DDHD2 →	+0.806	+0.426	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,575 associations by consensus.

PLPBP vs ASH2L — LSCC

Explore this scatter interactively →