PLPBP

Across TCGA patient cohorts, PLPBP mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLPBP-associated genes across cancer lineages are JNK2, Ku80, and Tuberin. Each is linked with PLPBP in more than 1 cancer types. Because this analysis shows association rather than direction, both PLPBP-to-partner and partner-to-PLPBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PLPBP-low versus PLPBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPBP→partner) and Y-score (partner→PLPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.291	+3.009	.003	.019	3	1
UCEC	Ku80 →	+0.427	+3.472	<.001	.002	3	1
UCEC	Tuberin →	+0.366	+2.179	.006	.034	3	1
UCEC	C-Raf →	+0.206	+3.459	.004	.005	3	1
UCEC	Cyclin-B1 →	+0.739	+3.459	.008	.005	3	1
UCEC	p62 Lck ligand →	+0.481	+3.179	.003	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK2 by PLPBP expression — UCEC

Explore this box plot interactively →