PLPBP

Across TCGA cell cohorts, PLPBP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,718 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLPBP-associated GO terms across cancer lineages are Negative regulation of sister chromatid cohesion, DNA-templated transcription initiation, and Protein-DNA complex disassembly. Each is linked with PLPBP in more than 13 cancer types. Because this analysis shows association rather than direction, both PLPBP-to-partner and partner-to-PLPBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of sister chromatid cohesion grouped by PLPBP-low versus PLPBP-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLPBP→partner) and Y-score (partner→PLPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of sister chromatid cohesion →	+0.132	+1.135	.002	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.091	+1.446	<.001	<.001	3	12
KIDNEY	Protein-DNA complex disassembly →	+0.173	+0.813	<.001	.003	3	11
BONE	Nucleosome disassembly →	+0.144	+0.846	<.001	<.001	3	11
LIVER	Negative regulation of cholesterol metabolic process →	+0.203	+1.131	<.001	.007	3	10
LIVER	Negative regulation of sterol biosynthetic process →	+0.199	+1.131	<.001	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,718 associations by consensus.

Negative regulation of sister chromatid cohesion by PLPBP expression — BLOOD_Myeloma

Explore this box plot interactively →