PLP2

Across TCGA cell cohorts, PLP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,464 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PLP2-associated GO terms across cancer lineages are Regulation of plasminogen activation, Type 2 mitophagy, and Regulation of cell-matrix adhesion. Each is linked with PLP2 in more than 13 cancer types. Because this analysis shows association rather than direction, both PLP2-to-partner and partner-to-PLP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of plasminogen activation grouped by PLP2-low versus PLP2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLP2→partner) and Y-score (partner→PLP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of plasminogen activation →	+0.251	+1.530	.008	.003	3	14
LUNG_NSCLC_LUSC	Type 2 mitophagy →	+0.256	+1.742	.004	.002	3	12
BONE	Regulation of cell-matrix adhesion →	+0.160	+0.934	<.001	.001	3	12
BONE	Membrane raft organization →	+0.148	+0.817	.003	.004	3	11
BONE	Regulation of focal adhesion assembly →	+0.151	+0.780	.001	.005	3	10
BONE	Regulation of cell-substrate junction assembly →	+0.151	+0.780	.001	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,464 associations by consensus.

Regulation of plasminogen activation by PLP2 expression — LUNG_NSCLC_LUSC

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