PLP1

Across TCGA pan-cancer cohorts, PLP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PLP1 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PLP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PLP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, GBM, and LSCC are the cancer types where PLP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.903	0.514	.046	2	view →
GBM	OS	Tertile	All	0.241	0.511	.033	2	view →
LSCC	DFS	Median	All	0.619	1.000	.030	2	view →
PDAC	DFS	Tertile	II,III,IV	0.810	1.000	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PLP1–HNSC (DFS)

Open the HNSC breakdown →